You have to pay attention to developer age, how many hours ago it was mixed, how many prints have been made, developer temperature etc.
Not really since print development typically goes to completion. This means that whatever effects aging developer has, are mostly on curve shape and not so much absolute sensitivity. The implication is that working with aging developer would necessitate (if anything) adjustment of your calibration curve, not so much exposure!
using 'factorial development'
That'll work fine and avoid most problems. Exposure can remain unchanged.
Exposure can be 'calibrated' using some kind of light metering device acting on base board level; this can be a regular light meter, lux meter, a fancy enlarging meter etc. Take your pick.